the effects of methanolic and chloroformic extracts of allium fistulosum l. on cell-mediated immune response in mice
نویسندگان
چکیده
garlic and onions as dietary constituents and medicines have been used for many disorders which dates back to the early civilization. it has been shown that different species of allium have immunomodulating effects. in this study, we sought to determine if methanolic and chloroformic extracts of allim fistulosum l. (leek) have any effect on cell-mediated immune response in mice. methanolic and chloroformic extracts of a. fistulosum bulbs were prepared by maceration. to study the effects of a. fistulosum on acquired immunity, groups of balb/c mice (n = 8-12) were used. sheep red blood cell (srbc) was injected (s.c., 1x108 cells/ml, 0.02 ml) and 5 days later, different extracts (1, 10, 100 and 1000 mg/kg), betamethasone (4 mg/kg) or normal saline were given i.p. after 1 h srbc was injected to footpad (s.c., 1x108 cells/ml, 0.02 ml) and footpad swelling was measured up to 72 h. to see the effects of a. fistulosum on intrinsic immunity the same procedure was used, but animals only received one injection of srbc 1 h after i.p. injection of test compounds. our findings showed that srbc induced an increase in paw swelling with maximum response at 7 h. betamethasone inhibited paw thickness in both models. in both intrinsic and acquired immunity models, chloroformic and methanolic extracts of a. fistulosum bulbs significantly reduced paw thickness at the doses of 100 and 1000 mg/kg, but no clear dose-response was observed.
منابع مشابه
The Effects of Allium hirtifolium Boiss. on Cell-Mediated Immune Response in Mice
Based on experiments showing immunomodulatory effects of garlic (Allium sativum L.), we sought to see whether Allium hirtifolim Boiss., belonging to the same genus of garlic, has any effect on immune responses. Hydroalcoholic extract and polyphenolic fraction of A. hirtifolium bulbs were prepared. Allicin (diallyl thiosulfinate), a biologically active component, was identified in plant bulbs...
متن کاملThe Effects of Allium hirtifolium Boiss. on Cell-Mediated Immune Response in Mice
Based on experiments showing immunomodulatory effects of garlic (Allium sativum L.), we sought to see whether Allium hirtifolim Boiss., belonging to the same genus of garlic, has any effect on immune responses. Hydroalcoholic extract and polyphenolic fraction of A. hirtifolium bulbs were prepared. Allicin (diallyl thiosulfinate), a biologically active component, was identified in plant bulbs...
متن کاملthe effects of chloroform, ethyl acetate and methanolic extracts of brassica rapa l. on cell-mediated immune response in mice
turnips with a long history of usage, are helpful in preventing breast and prostate cancer, inflammation and body`s immune system dysfunction. in this study, we investigated the effects of chloroform, ethyl acetate and methanolic extracts of brassica rapa l. on cell-mediated immune response in mice. chloroform, ethyl acetate and methanolic extracts of b. rapa glands were prepared by maceration ...
متن کاملthe effects of chloroform, ethyl acetate and methanolic extracts of brassica rapa l. on cell-mediated immune response in mice
متن کامل
The effects of chloroform, ethyl acetate and methanolic extracts of Brassica rapa L. on cell-mediated immune response in mice
Turnips with a long history of usage, are helpful in preventing breast and prostate cancer, inflammation and body`s immune system dysfunction. In this study, we investigated the effects of chloroform, ethyl acetate and methanolic extracts of Brassica rapa L. on cell-mediated immune response in mice. Chloroform, ethyl acetate and methanolic extracts of B. rapa glands were prepared by maceration ...
متن کاملthe effects of allium hirtifolium boiss. on cell-mediated immune response in mice
based on experiments showing immunomodulatory effects of garlic (allium sativum l.), we sought to see whether allium hirtifolim boiss., belonging to the same genus of garlic, has any effect on immune responses. hydroalcoholic extract and polyphenolic fraction of a. hirtifolium bulbs were prepared. allicin (diallyl thiosulfinate), a biologically active component, was identified in plant bulbs by...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۱، شماره ۲، صفحات ۵۹-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023